Actively Recruiting
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Led by Massachusetts General Hospital · Updated on 2026-05-11
120
Participants Needed
1
Research Sites
202 weeks
Total Duration
On this page
Sponsors
M
Massachusetts General Hospital
Lead Sponsor
B
Boston University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.
CONDITIONS
Official Title
Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 18 and 55 years old
- Have experienced a psychotic disorder or mood disorder
You will not qualify if you...
- Have any neurological disorder or current substance use disorder within the past 6 months
- Not be proficient in English
- Have had a recent change in medication or an acute symptom presentation
- Meet standard MRI exclusion criteria such as having metal in the body, claustrophobia, or a history of head trauma
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Charlestown, Massachusetts, United States, 02129
Actively Recruiting
Research Team
D
Daphne J Holt, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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