Actively Recruiting
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
Led by University of Michigan · Updated on 2026-04-27
294
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
N
National Institute on Drug Abuse (NIDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study seeks to understand individual differences in personality, brain function, and behavior. Study hypothesis: \- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.
CONDITIONS
Official Title
Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18-22 years old at baseline
- Right-handed
- Medically/physically able to give informed consent
- English-speaking
- Substance use is free to vary, but for participants with a history of substance use, 1 use of cannabis (including less than a full dose)
You will not qualify if you...
- Acute or chronic medical or neurological illness (e.g., diabetes, epilepsy, migraine)
- History of psychosis in self or first-degree relative
- Current treatment for substance use disorder
- Current or past 6-month treatment with centrally acting medications (not including attention deficit hyperactivity disorder (ADHD) medication)
- Intelligence quotient (IQ) < 70
- Lifetime history of head trauma with loss of consciousness > 5 minutes
- Reliance on glasses to be able to read small text at a distance of approximately 30 inches
- Colorblindness
- MRI contraindication (e.g., pregnancy, metal implants, claustrophobia) per protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Rachel Upjohn Building
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
2
University of Michigan
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
Research Team
P
Paul Holdefer, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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