Actively Recruiting
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
Led by University of Cambridge · Updated on 2024-07-17
50
Participants Needed
1
Research Sites
193 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to to look for changes within the brain, and changes in body-to-brain signals in people with cancer and people who do not have cancer. The main questions it aims to answer are: 1. Are there differences in areas of the brain known to be related to appetite control, food reward and motivation, between participants with cancer related weight loss and healthy volunteers 2. Do responses to questionnaires and computer based tasks suggest participants with cancer related weight loss have reduced appetite and reduced motivation to eat compared to healthy volunteers, and if so, do questionnaires suggest that this is associated with any other symptoms? Researchers will compare the structure and blood flow in relevant areas of the brain using MRI images between participants with cancer related weight loss and healthy volunteers. Participants will complete questionnaires and computer based tasks to allow researchers to assess areas of the brain which become more active in response to different stimuli. Some computer based tasks will be performed during the MRI scan. This is called functional MRI. A further objective is to obtain an archive of blood samples which will be stored securely for future analysis if relevant hormones or analytes are identified that may be relevant to metabolism or body composition
CONDITIONS
Official Title
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Aged 18 years or over
- Willing and able to comply with study procedures and visits
- For cancer participants: Diagnosis of cancer or confirmed non-intracranial malignancy on imaging
- For cancer participants: Unintended weight loss of more than 5% body weight in 6 months or reported weight loss/change in appetite
You will not qualify if you...
- Non-fluent English speaker
- Active infection or requiring antibiotics
- Women who are pregnant, planning pregnancy, or lactating
- Contraindications for MRI
- Significant acute, chronic, or psychiatric conditions that pose undue risk or interfere with study
- Metabolically or clinically unstable on study day
- Receiving artificial nutrition
- Taking medications that may affect appetite, cognition, or study task completion
- Weight or body size exceeding MRI scanner limit (220kg)
- Unresolved obstructive gastrointestinal lesion
- For cancer participants: Intracranial cancer or brain metastases
- For healthy volunteers: Current or recovering from any cancer
- For healthy volunteers: Unintentional weight loss over 5% or unexplained loss of appetite
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Cambridge
Cambridge, United Kingdom, CB20QQ
Actively Recruiting
Research Team
A
Anthony P Coll, MD PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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