Actively Recruiting
The Neurobiological Effect of 5-HT2AR Modulation
Led by Gitte Moos Knudsen · Updated on 2024-12-16
200
Participants Needed
1
Research Sites
691 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators wish to investigate neurobiological effects of serotonin 2A receptor modulation in healthy volunteers, contrasting effects of an agonist (psilocybin) and an antagonist (ketanserin). Magnetic resonance imaging (MRI) and positron emission tomography (PET) will be used as neuroimaging tools.
CONDITIONS
Official Title
The Neurobiological Effect of 5-HT2AR Modulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy individuals above 18 years of age
You will not qualify if you...
- Presence of or previous primary psychiatric disease (DSM axis 1 or WHO ICD-10 diagnostic classifications) or in first-degree relatives
- Previous or present neurological condition/disease, significant somatic condition/disease or intake of drugs suspected to influence test results
- Non-fluent Danish language skills
- Vision or hearing impairment
- Previous or present learning disability
- Pregnancy
- Breastfeeding
- Contraindications in regard to MRI scanning
- Alcohol or drug abuse
- Allergy to test drugs
- Participation in studies with more than 10 mSv radiation exposure
- Abnormal ECG or intake of QT prolonging medication
- Previous significant side-effects to hallucinogenic drugs
- Use of hallucinogenic drugs 6 months before inclusion
- Blood donation 3 months before and after participation
- Body weight under 50 kg
- Plasma ferritin levels outside normal range
- Ethical concerns regarding psychedelic drug administration (for Subproject 2c specific exclusions)
AI-Screening
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Trial Site Locations
Total: 1 location
1
Neurobiology Research Unit, Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
Research Team
G
Gitte M Knudsen, Professor
CONTACT
P
Patrick M Fisher, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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