Actively Recruiting
Neurocognition After Radiotherapy in CNS- and Skull-base Tumors
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-05-08
120
Participants Needed
3
Research Sites
207 weeks
Total Duration
On this page
Sponsors
U
Universitaire Ziekenhuizen KU Leuven
Lead Sponsor
U
University Hospital, Ghent
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this multicenter prospective longitudinal study is to study the long-term impact of multimodal treatment (chemotherapy, radiotherapy and surgery) in adult brain and base of skull tumors on neurocognitive functioning. All included patients will complete a self-report inventory (subjective cognitive functioning, QoL, confounders), a cognitive test battery, an advanced MR at multiple timepoints. Moreover, toxicity will be scored according to the CTCAEv5.0 in these patients over time.
CONDITIONS
Official Title
Neurocognition After Radiotherapy in CNS- and Skull-base Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (18 years or older at diagnosis) with a primary brain or base of skull tumor
- Patients eligible for conventionally fractionated radiotherapy (photon or proton irradiation)
You will not qualify if you...
- Tumors with poor prognosis such as incompletely resected IDH-wild-type glioma
- Completely resected IDH-wild-type and MGMT-promotor unmethylated glioma
- Grade III meningioma
- H3K27M+ midline glioma
- Tumors requiring craniospinal or whole ventricular irradiation
- Hypofractionated or stereotactic radiation (fraction size greater than 2 Gy)
- Inability to perform cognitive tests or self-reports due to motor, sensory, or language difficulties
- Documented mental retardation before diagnosis
- Pre-existing psychiatric diagnoses causing cognitive deficits (e.g., psychoses, autism, learning disorders)
- Previous relapse treated by chemotherapy and/or radiation therapy
- Genetic syndromes such as Down syndrome
- Unable to undergo MRI due to claustrophobia or metallic implants like pacemaker, ICD, or neurostimulator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
University Hospitals Ghent
Ghent, Belgium
Actively Recruiting
2
UZ Leuven
Leuven, Belgium
Actively Recruiting
3
Gasthuis Zusters Antwerpen
Wilrijk, Belgium
Actively Recruiting
Research Team
L
Laurien De Roeck, MD
CONTACT
M
Maarten Lambrecht, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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