Actively Recruiting
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2025-07-03
24
Participants Needed
2
Research Sites
697 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a trial that evaluates the preservation of cognition and neuropsychiatric function following genu-sparing whole brain radiation in patients with brain metastases.
CONDITIONS
Official Title
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologic or cytologic proof of solid tumor malignancy from primary or metastatic site
- Mini Mental State Examination (MMSE) score 24 or higher
- Age 18 years or older
- Karnofsky Performance Status (KPS) 70 or higher
- No metastases in the genu of the corpus callosum
- Scheduled to undergo whole brain radiation therapy for brain metastases
- Patients of childbearing potential must use effective contraception
- Ability to understand and willingness to sign informed consent
- Informed of investigational nature and provided written consent
- Life expectancy of at least 6 months
- Prior stereotactic radiosurgery (SRS) for brain metastases allowed
You will not qualify if you...
- Prior whole brain radiation therapy
- MMSE score below 24
- Brain metastases located in the genu of the corpus callosum
- Serious medical or psychiatric illness preventing informed consent or treatment completion
- Karnofsky Performance Status (KPS) below 70
- Non-native English speakers
- Absolute contraindication to MRI imaging
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
2
The SKCCC at Johns Hopkins
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
K
Kristin Redmond, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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