Understanding How Stroke Affects Sentence Production in Aphasia Studying Brain and Language Changes in Adults 18 and Older

What this Trial Is About

This research focuses on post-stroke agrammatic aphasia PSA-G, a condition that affects sentence production with symptoms like fragmented sentences, slow speech, and errors in grammar. The study aims to better understand how different language, motor, and cognitive processes work together to produce fluent sentences and how these break down in PSA-G compared to other types of post-stroke aphasia. This work supports the development of improved language interventions and aligns with priorities to understand and treat communication impairments after stroke. Participants will engage in language tasks involving speaking and understanding words and sentences with various linguistic challenges, such as morphological and semantic changes, phonological priming, and tense production. The study uses behavioral methods combined with brain imaging, specifically magnetoencephalography MEG, to explore how brain activity supports sentence production in people with aphasia and neurotypical adults. This is a single-arm study where all participants complete these language conditions to measure accuracy, response time, and brain function. During the study, participants will perform speech and comprehension tasks while researchers record their response accuracy, the speed of responses, and brain activity over about one year. This includes detailed assessments of how language is processed in the brain and how it changes in aphasia. The study also includes neurotypical adults for comparison. The findings aim to inform more targeted and effective treatments for aphasia and improve understanding of the neural basis of sentence production.

Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia