Actively Recruiting
Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
Led by University of Arkansas · Updated on 2026-05-06
255
Participants Needed
1
Research Sites
280 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The proposed clinical trial would evaluate the use of smartphone applications ("apps", which have well-established efficacy in reducing cigarette and alcohol use) to prevent relapse among patients receiving medication-assisted treatment for opioid use disorder. In addition to standard app-based self-monitoring of drug use and personalized feedback, project innovation is enhanced by the proposed use of location-tracking technology for targeted, personalized intervention when participants enter self-identified areas of high risk for relapse. Furthermore, the proposed sub-study would use longitudinal functional neuroimaging to elucidate the brain-cognition relationships underlying individual differences in treatment outcomes, offering broad significance for understanding and enhancing the efficacy of this and other app-based interventions.
CONDITIONS
Official Title
Neurocognitive Mechanisms Underlying Smartphone-Assisted Prevention of Relapse in Opioid Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female sex
- Age 18 years and older
- For MRI sub-study: age 18 to 50 years old
- Currently in Phase I of medication-assisted treatment for opioid use disorder (no more than one week of take-home medications at each weekly clinic visit)
- Willing to use a smartphone if randomized to the smartphone app intervention
- For MRI sub-study: native English speaker
You will not qualify if you...
- History of neurological, cardiovascular, or infectious disease
- History of brain trauma with loss of consciousness of 20 minutes or more
- Positive pregnancy test prior to MRI
- MRI contraindications including presence of non-removable internal or external ferromagnetic objects, claustrophobia, medications interfering with hemodynamic coupling, hypersensitivity to loud noise, or body circumference over 60 cm due to broad shoulders or obesity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brain Imaging Research Center
Little Rock, Arkansas, United States, 72227
Actively Recruiting
Research Team
A
Andrew James, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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