Actively Recruiting
Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
Led by University of Michigan · Updated on 2025-06-06
110
Participants Needed
1
Research Sites
224 weeks
Total Duration
On this page
Sponsors
U
University of Michigan
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enhanced using neurofeedback. The study hypotheses include: * Participants receiving veritable-Neurofeedback (NF) will show a greater activation increases in the prefrontal cortex (PFC) compared to sham-NF * Participants receiving veritable-NF will show greater cognitive reappraisal (CR) ability compared to those receiving sham-NF * PFC activation will positively correlate with CR ability
CONDITIONS
Official Title
Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary diagnosis of generalized anxiety disorder, social anxiety disorder, panic disorder, or illness anxiety disorder
- Score of 2 or more on at least 1 question from GAD/CROSS-AD composite
- Medically and physically able to consent
- Not regularly taking psychotropic medications except stable doses of buspirone or antidepressants for at least 4 weeks
- Using the same oral hormonal contraceptive for at least 3 months if applicable
- For females, not currently pregnant or trying to become pregnant
- Ability to tolerate small, enclosed spaces without anxiety
- No metals or implants that interfere with MRI
- Size compatible with scanner gantry
You will not qualify if you...
- Current diagnosis of Obsessive Compulsive Disorder, Posttraumatic Stress Disorder, or Bipolar Disorder
- Current substance abuse or dependence in past 6 months
- Active suicidality with plan or intent
- Current psychosis
- History of serious neurological illness or medical condition compromising brain function
- History of closed head injury with loss of consciousness greater than approximately 5 minutes or hospitalization due to head injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
Research Team
S
Sophia Hovakimian
CONTACT
L
Laura Stchur, MSW
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here