Brain Activity Feedback Training Using the Supplementary Motor Area for Adolescents with Tourette Syndrome or Chronic Tic Disorder Aged 10 to 16 Years

What this Trial Is About

This clinical trial involves adolescents aged 10 to 16 years with Tourette Syndrome or chronic tic disorder. The study evaluates the effects of neurofeedback training targeting the supplementary motor area SMA compared to neurofeedback from a control brain region. Participants are randomized to one of these two groups to assess changes in symptoms and brain activity control related to their condition. Participants undergo three neurofeedback training sessions using real-time functional magnetic resonance imaging fMRI. Each session includes six neurofeedback scans where participants are cued to increase or decrease activity in the target brain region while watching feedback represented as a line graph. The experimental group receives feedback from the SMA, while the control group receives feedback from a different brain region. During the trial, participants attend multiple MRI sessions to complete the neurofeedback training and assessments. Researchers measure changes in Tourette symptoms at baseline, 4 days, 2 weeks, and 1 month after training, along with participants ability to control brain activity during neurofeedback. Safety and eligibility are monitored throughout, including assessments for brain region localization during MRI scans. The total study duration includes training and follow-up assessments over approximately one month.

Neurofeedback From the Supplementary Motor Area for Tourette Syndrome