Actively Recruiting
Neurofeedback to Treat Depression - 2
Led by University of Pennsylvania · Updated on 2025-12-04
80
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD. This real-time fMRI neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate task stimuli (in a closed loop) based on this state.
CONDITIONS
Official Title
Neurofeedback to Treat Depression - 2
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Gender inclusive
- Adult aged 18 to 65
- Meets DSM-5 criteria for MDD according to the Clinician-Administered MDD Scale (unipolar depression or bipolar II depressed)
- Minimum score of 16 on Montgomery Asberg Depression Rating Scale (MADRS)
- Normal cognition
- Able to read and understand English
- Able to provide consent
You will not qualify if you...
- Pregnancy (female participants)
- Outside age range
- MRI contraindications (medical implant, claustrophobia, etc.)
- Use of psychoactive medication or currently in therapy
- Neurological disorder or conditions impacting brain data or causing depression
- Co-morbid psychotic or neurological disorders
- Developmental or cognitive disabilities or impairments
- Active alcohol or drug abuse/dependence within past 6 months
- Non-English speaking
- Non-correctable vision loss
- Refusal to provide informed consent
- Active suicide risk
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Center for Neuromodulation in Depression and Stress
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
Y
Yvette Sheline, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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