Actively Recruiting
Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
Led by Lancashire Teaching Hospitals NHS Foundation Trust · Updated on 2025-04-08
360
Participants Needed
1
Research Sites
244 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
There is not much known about why some people develop seizures in adulthood, but some researchers think that it might be a warning from the body to highlight something may be wrong with the brain. A small number of people with first seizure in adulthood go on to experience problems like stroke or dementia later in life. However, stroke and dementia are common diseases, so it is not know whether there is a real association between these conditions. When people develop their first seizure in adult life, this is sometimes called Late-Onset Epilepsy. The NeuroFrailty study, will observe 'brain health' over the years following the onset of a seizure, to provide more information about people with these kinds of seizures.
CONDITIONS
Official Title
Neurofrailty: A Study of Late-onset Epilepsy and Its Associations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of late-onset epilepsy or first seizure after age 18
- Diagnosis confirmed or established at a tertiary neurology centre
- Sequential cases will be used; an annual cap of 150 patients per year per cohort may apply
- For control participants: established diagnosis of migraine
- Control participants may be with or without therapeutic medications with antiepileptic properties
You will not qualify if you...
- Seizures caused by a lesion such as malignancy, stroke (excluding transient ischaemic attack), hypoxic brain injury, trauma, or vascular/congenital abnormalities likely causing seizures
- For control participants: diagnosis of epilepsy or confirmed seizure
- People with migraine or headache syndrome can be included in case group; seizure syndrome presence is mutually exclusive between case and control groups
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lancashire Teaching Hospitals NHS
Preston, Lancashire, United Kingdom, PR2 9HT
Actively Recruiting
Research Team
J
Jasmine Wall, MB BChir
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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