Precision Neuroimaging of Parkinson's Disease

What this Trial Is About

Parkinson's Disease (PD) is a neurodegenerative disorder affecting both subcortical structures and the cortex, leading to symptoms like tremor, slow movements, gait freezing, sleep problems, and autonomic dysfunction. Researchers recently identified a brain system called the Somato-Cognitive Action Network (SCAN), which may play a key role in PD dysfunction. This study aims to use advanced magnetic resonance imaging to explore how SCAN connects to subcortical areas involved in PD and whether these connections differ in PD patients compared to healthy controls. Participants include individuals diagnosed with PD as well as healthy controls without neurological issues or family history of PD. The study involves multiple imaging sessions over six months—3 to 4 sessions for healthy individuals and 6 to 8 sessions for PD patients. These sessions focus on mapping brain connectivity between SCAN and subcortical motor regions. The goal is to better understand SCAN's role in PD and its potential as a target for future neuromodulatory treatments, such as less-invasive cortical stimulation approaches. During the study, participants will undergo brain scans and assessments to evaluate the connections between motor circuits and SCAN. Researchers will measure cortico-subcortical connectivity and compare differences between PD patients and controls. The study includes monitoring cognitive status to exclude dementia and uses screening to ensure participants can safely undergo MRI scans. The findings may help improve evaluation tools and treatment targets for PD by focusing on SCAN-related brain networks.

Neuroimaging of Parkinson's