Actively Recruiting
Neuroimaging of Parkinson's
Led by Washington University School of Medicine · Updated on 2026-04-13
120
Participants Needed
1
Research Sites
282 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.
CONDITIONS
Official Title
Neuroimaging of Parkinson's
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of Parkinson's Disease for PD participants
- Must not meet criteria for dementia
- For healthy controls: normal or benign neurological exam
- For healthy controls: normal cognition
- For healthy controls: no first-degree relatives with Parkinson's Disease
- Must meet specific health and cognitive criteria depending on the group
- Age 40 years or older
You will not qualify if you...
- Any neurological condition other than Parkinson's Disease
- History of significant head injury with loss of consciousness over 5 minutes or neurological sequelae
- Diagnosis of schizophrenia, bipolar disorder, or epilepsy
- Serious medical conditions including end-stage organ failure or ongoing cancer treatment
- Diagnosis of dementia or cognitive impairment (MMSE score <24 or MoCA score <21)
- MRI contraindications including metal implants, claustrophobia, or weight over 300 lbs due to MRI scanner limits
AI-Screening
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Trial Site Locations
Total: 1 location
1
East Imaging Building
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
D
Danny Bower
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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