Actively Recruiting
Neuroimmune Responses to Exercise in Chronic Back Pain
Led by McGill University · Updated on 2026-03-27
216
Participants Needed
1
Research Sites
212 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this mechanistic clinical trial is to learn how physical exercise affects the body and brain in people with chronic low back pain. The study will examine whether a 12-week online exercise program changes these measures compared with a waitlist group. Researchers will also study immune activity and brain function in people with chronic low back pain and compare them with healthy participants. Participants will complete questionnaires, provide blood samples, and undergo brain imaging scans.
CONDITIONS
Official Title
Neuroimmune Responses to Exercise in Chronic Back Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Diagnosis of chronic primary low back pain persistent for at least 3 months or recurrent for at least half the days in the past 6 months
- Low back pain intensity of at least 4 on a 0-10 pain scale
- Healthy controls must be aged between 18 and 75 years
You will not qualify if you...
- Presence of red flags indicating serious pathology related to low back pain
- Predominant nociceptive or neuropathic pain mechanisms confirmed by clinical assessment
- Presence of chronic or acute pain more severe or disabling in other body areas than the low back
- History of diabetes, neurological, or psychiatric disorders
- Significant cardiorespiratory problems or contraindications to physical exercise as per PAR-Q+
- Currently following a structured physical exercise program exceeding 60 minutes per week
- Contraindications to MRI including metallic implants, pregnancy, or claustrophobia
- Healthy controls with any acute or chronic pain conditions or above exclusion criteria
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Montreal General Hospital
Montreal, Quebec, Canada, H3H 1V6
Actively Recruiting
Research Team
C
Carlos Gevers Montoro, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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