Actively Recruiting
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients
Led by Imperial College London · Updated on 2025-02-07
18
Participants Needed
2
Research Sites
117 weeks
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
M
Merck Sharp & Dohme LLC
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is being done in order to understand what causes people to have a chronic cough, which is defined as a cough lasting for more than 8 weeks. The research team wish to find out whether there is any inflammation in the lungs of patients with chronic cough. The research team will also determine whether a suspected chemical produced in the body, called adenosine triphosphate (ATP) can be responsible for causing the chronic cough. In order to be able to find out what is abnormal in those who have a chronic cough, The research team will need to compare their results with those that do not have a chronic cough. In this study, the research team will examine 10 participants who suffer from chronic cough and 8 individuals who do not have a chronic cough and are healthy.
CONDITIONS
Official Title
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy non-smoking individuals with no significant disease, no history of asthma or rhinitis, no therapies, baseline FEV1 ≥80% predicted with FEV1/FVC ratio >70%, and non-smoker for at least 12 months with a pack history of ≤5 pack-years
- Participants with chronic cough lasting at least 8 weeks and followed in the Cough Clinic for at least 6 months
- Participants who have undergone diagnostic evaluation as recommended by ERS guidelines for cough management
- Participants with an identifiable cause for cough that has failed targeted therapies or with chronic idiopathic cough with no identifiable cause
- Male or female aged 30 to 70 years at screening
- Able to complete the study and all measurements
- Able to read, comprehend, and write sufficiently to complete study materials
- Provided written informed consent prior to participation
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Royal Brompton & Harefield NHS Trust,
London, United Kingdom, SW3 6HP
Actively Recruiting
2
Royal Brompton Hospital
London, United Kingdom, SW3 6HP
Actively Recruiting
Research Team
K
Kian Fan Chung, MD
CONTACT
P
Pankaj Bhavsar, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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