Study of ATP and P2X3 Receptor Involvement in Airways of Adults with Chronic Cough

What this Trial Is About

Chronic cough, defined as a cough lasting more than 8 weeks, is a common condition that can be difficult to treat due to unclear causes. This research aims to understand whether inflammation in the lungs and a substance called adenosine triphosphate ATP play roles in chronic cough. The study will compare findings from people with chronic cough to healthy individuals to identify what may be abnormal in those affected. The study will involve 10 participants with chronic cough and 8 healthy individuals without cough. Researchers will examine whether ATP is released in the airways and whether it activates receptors called P2X3, which may contribute to cough hypersensitivity. Participants with chronic cough will have a history of cough lasting at least 8 weeks and have undergone diagnostic evaluations, while healthy participants must be free from significant lung diseases and smoking history. Participants will undergo assessments to detect the presence of ATP and P2X23 receptors in their airways and to measure sensitivity to ATP. The study will also evaluate how ATP affects inflammatory responses in the upper and lower airways. The total study duration includes follow-up of up to 18 months to monitor cough and laryngeal sensitivity along with inflammation markers.

Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients