Actively Recruiting
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients: an Exploratory Study
Led by Imperial College London · Updated on 2025-02-07
18
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
Sponsors
I
Imperial College London
Lead Sponsor
M
Merck Sharp & Dohme LLC
Collaborating Sponsor
AI-Summary
What this Trial Is About
Chronic cough, defined as a cough lasting more than 8 weeks, is a common condition that can be difficult to treat due to unclear causes. This research aims to understand whether inflammation in the lungs and a substance called adenosine triphosphate (ATP) play roles in chronic cough. The study will compare findings from people with chronic cough to healthy individuals to identify what may be abnormal in those affected. The study will involve 10 participants with chronic cough and 8 healthy individuals without cough. Researchers will examine whether ATP is released in the airways and whether it activates receptors called P2X3, which may contribute to cough hypersensitivity. Participants with chronic cough will have a history of cough lasting at least 8 weeks and have undergone diagnostic evaluations, while healthy participants must be free from significant lung diseases and smoking history. Participants will undergo assessments to detect the presence of ATP and P2X2/3 receptors in their airways and to measure sensitivity to ATP. The study will also evaluate how ATP affects inflammatory responses in the upper and lower airways. The total study duration includes follow-up of up to 18 months to monitor cough and laryngeal sensitivity along with inflammation markers.
CONDITIONS
Brief Title
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy individuals with no significant disease, no history of asthma or rhinitis, no therapies, baseline lung function with FEV1 ≥80% predicted and FEV1/FVC ratio >70%, non-smokers for at least 12 months with smoking history ≤5 pack-years
- Participants with chronic cough lasting at least 8 weeks, followed in a cough clinic for at least 6 months
- Participants have undergone diagnostic evaluation as recommended by ERS guidelines
- Participants with either an identifiable cause of cough that has not improved with treatment or chronic idiopathic cough with no identified cause
- Males or females aged 30 to 70 years at screening
- Able to provide written informed consent and complete study procedures
- Able to read, understand, and write sufficiently to complete study materials
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 18 months
Participants undergo diagnostic assessments to evaluate cough characteristics and airway receptor presence.
Multiple visits over 18 months for assessments
Duration - Up to 18 months
Participants are monitored to observe ATP presence, cough sensitivity, and inflammatory responses in the airways.
Periodic visits over 18 months for follow-up evaluations
Trial Site Locations
Total: 2 locations
1
Royal Brompton & Harefield NHS Trust,
London, United Kingdom, SW3 6HP
Actively Recruiting
2
Royal Brompton Hospital
London, United Kingdom, SW3 6HP
Actively Recruiting
Research Team
K
Kian Fan Chung, MD
P
Pankaj Bhavsar, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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