Substance P expression in human tooth pulp in relation to caries and pain experience.
H D Rodd, F M Boissonade
https://pubmed.ncbi.nlm.nih.gov/11153921Actively Recruiting
Led by Sheffield Teaching Hospitals NHS Foundation Trust · Updated on 2024-10-09
60
Participants Needed
1
Research Sites
8 weeks
Total Duration
S
Sheffield Teaching Hospitals NHS Foundation Trust
Lead Sponsor
U
University of Sheffield
Collaborating Sponsor
Dentine hypersensitivity (sensitive teeth) is a common dental condition where exposed dentine causes sharp pain in response to stimuli like cold or air. This study aims to explore how brain activity measured by electroencephalography (EEG) responds to tooth stimulation and whether these responses differ between people with and without dentine sensitivity. Understanding these brain responses could improve how dental pain is assessed and treated. The study compares EEG responses to tooth stimulation in two groups: patients with dentine sensitivity and those without. EEG involves wearing a cap with small sensors that record brain signals during tooth exposure to cold temperatures and short air bursts. The researchers will analyze these brain signals to see how the central nervous system processes painful stimuli from the teeth. Participants will undergo EEG recording while their teeth are stimulated, lasting about one hour. They will also complete a questionnaire about their dentine sensitivity experience. The study will measure EEG responses and correlate them with patient-reported sensitivity scores. This information may help develop objective methods to evaluate dentine sensitivity and compare treatment effectiveness. Participation involves a single visit with non-invasive assessments and lasts until study completion in 2025.
CONDITIONS
Neurological Responses in Patients with Dentine Hypersensitivity
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 1 hour
Participants undergo EEG recording to measure brain responses to tooth sensitivity stimuli.
1 visit (in-person)
Total: 1 location
1
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom, S10 2JF
Actively Recruiting
F
Fiona Boissonade, BDS, PhD
N
Natalie Wong, PhD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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