Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
NCT06633627

Neurological Responses in Patients with Dentine Hypersensitivity

Led by Sheffield Teaching Hospitals NHS Foundation Trust · Updated on 2024-10-09

60

Participants Needed

1

Research Sites

50 weeks

Total Duration

On this page

Sponsors

S

Sheffield Teaching Hospitals NHS Foundation Trust

Lead Sponsor

U

University of Sheffield

Collaborating Sponsor

AI-Summary

What this Trial Is About

Dentine hypersensitivity (also known as sensitive teeth) is a common dental condition in which the dentine, a layer of sensitive hard tissue under the enamel of the teeth, becomes exposed making the teeth sensitive to stimuli, such as hot and cold. It poses a significant challenge for clinicians and affects patients' quality of life. The overall aim of the study is to understand if a way of measuring brain activity (electroencephalography \[EEG\]) shows a response to tooth stimulation, and see how these responses may be different in patients with dentine sensitivity. EEG records brain signals and can provide information about how the brain processes painful stimuli. EEG recording is a non-evasive and painless procedure. It involves using a cap with small sensors called electrodes to pick up brain signals. During the EEG assessment appointment, brain signals will be recorded throughout the duration when cold temperatures and short bursts of air are applied to the tooth. Brain signals recorded during tooth stimulation from participants with and without dentine sensitivity will then be compared to explore if there are any differences. The investigators hope that EEG responses could be helpful to objectively assess dentine sensitivity, further the understanding of brain processing of dental pain, and allow the comparison of the effectiveness of different treatment options in the future. This information may help to improve treatments and the quality of life for patients with dentine sensitivity and potentially other types of dental pain.

CONDITIONS

Official Title

Neurological Responses in Patients with Dentine Hypersensitivity

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  1. Adults 18 years and older;
  2. Understands and is willing, able and likely to comply with all study procedures and restrictions;
  3. Accepts the form of the study and signs a declaration of informed consent;
  4. In good health (in the opinion of the clinical dental professional);
  5. A minimum of 10 teeth not including teeth with crowns or bridges from upper right 4 to upper left 4 and lower right 4 to lower left 4;

For patients with dentine sensitivity only (experimental group): self-reported sensitivity in at least 1 tooth; confirmed by response to air puff.

Not Eligible

You will not qualify if you...

  1. Adults currently using maxillary or mandibular orthodontic appliances;
  2. Obvious signs of untreated caries, which in the opinion of the clinical dental professional, will affect the scientific validity of the study;
  3. Periodontal pocket depth ≥4mm in the anterior upper or lower sextants;
  4. Evidence of periodontitis.
  5. Have a history of seizures;
  6. Taking medications that affect brain responses;
  7. Experience damaged skin on the scalp due to cuts, psoriasis, eczema, or other conditions;
  8. Any participant who in the investigator's judgment will not comply with the study protocol;
  9. Any participant who has difficulties in adequate understanding of English.

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Trial Site Locations

Total: 1 location

1

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom, S10 2JF

Actively Recruiting

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Research Team

F

Fiona Boissonade, BDS, PhD

CONTACT

N

Natalie Wong, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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