Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID06633627

Identification and Quantification of Neurological Responses in Patients with Dentine Hypersensitivity

Led by Sheffield Teaching Hospitals NHS Foundation Trust · Updated on 2024-10-09

60

Participants Needed

1

Research Sites

8 weeks

Total Duration

On this page

Sponsors

S

Sheffield Teaching Hospitals NHS Foundation Trust

Lead Sponsor

U

University of Sheffield

Collaborating Sponsor

AI-Summary

What this Trial Is About

Dentine hypersensitivity (sensitive teeth) is a common dental condition where exposed dentine causes sharp pain in response to stimuli like cold or air. This study aims to explore how brain activity measured by electroencephalography (EEG) responds to tooth stimulation and whether these responses differ between people with and without dentine sensitivity. Understanding these brain responses could improve how dental pain is assessed and treated. The study compares EEG responses to tooth stimulation in two groups: patients with dentine sensitivity and those without. EEG involves wearing a cap with small sensors that record brain signals during tooth exposure to cold temperatures and short air bursts. The researchers will analyze these brain signals to see how the central nervous system processes painful stimuli from the teeth. Participants will undergo EEG recording while their teeth are stimulated, lasting about one hour. They will also complete a questionnaire about their dentine sensitivity experience. The study will measure EEG responses and correlate them with patient-reported sensitivity scores. This information may help develop objective methods to evaluate dentine sensitivity and compare treatment effectiveness. Participation involves a single visit with non-invasive assessments and lasts until study completion in 2025.

CONDITIONS

Brief Title

Neurological Responses in Patients with Dentine Hypersensitivity

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults 18 years and older
  • Willing and able to comply with all study procedures and restrictions
  • Able to give informed consent
  • In good health as judged by a dental professional
  • Have at least 10 natural teeth without crowns or bridges in the front and side areas
  • For dentine sensitivity group: self-reported sensitivity in at least one tooth confirmed by response to air puff
Not Eligible

You will not qualify if you...

  • Currently using upper or lower orthodontic appliances
  • Untreated dental caries affecting study validity
  • Periodontal pocket depth of 4mm or more in front upper or lower teeth
  • Evidence of periodontitis
  • History of seizures
  • Taking medications affecting brain responses
  • Damaged scalp skin from cuts, psoriasis, eczema, or other conditions
  • Unable to comply with study protocol
  • Difficulty understanding English

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Diagnostic Evaluation

Duration - 1 hour

Participants undergo EEG recording to measure brain responses to tooth sensitivity stimuli.

1 visit (in-person)

Trial Site Locations

Total: 1 location

1

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom, S10 2JF

Actively Recruiting

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Research Team

F

Fiona Boissonade, BDS, PhD

N

Natalie Wong, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

Frequently Asked Questions

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A Kaewpitak, C S Bauer, E P Seward...

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