Actively Recruiting
Neuromodulation and Attention Deficits in MDD
Led by University of Electronic Science and Technology of China · Updated on 2025-08-08
60
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Multimodal study (Behavior, TMS, EEG) combining a sham-controlled intermittent theta burst stimulation (iTBS) intervention with an additional-singleton task and EEG to evaluate whether left dorsolateral prefrontal cortex (DLPFC) stimulation enhances cognitive control and modulates maladaptive attention processes in MDD and whether the effects are influenced by neuronavigated versus manual (Beam F3 method) localization of the stimulation site.
CONDITIONS
Official Title
Neuromodulation and Attention Deficits in MDD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 55 years
- Right-handed
- Normal or corrected normal vision
- Diagnosis of Major Depressive Disorder meeting DSM-5 criteria, either unmedicated or on stable medication for at least one month
- Healthy participants must have no past or present psychiatric or neurological disorders
You will not qualify if you...
- Diagnosis of other severe mental disorders like schizophrenia, bipolar disorder, or neurodevelopmental disorders
- High suicidal risk
- Unusual intellectual functioning or hearing impairments
- Received neuromodulation treatments such as Modified Electroconvulsive Therapy (MECT) or psychotherapy within the last 6 months
- For active treatment group only: contraindications to MRI scanning such as metal implants or claustrophobia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Clinical Hospital of Chengdu Brain Science Institute, Chengdu Fourth People's Hospital, Jiujiang Branch (Chengdu Mental Health Center)
Chengdu, Sichuan, China, 610041
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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