Actively Recruiting

Early Phase 1
Age: 18Years - 99Years
All Genders
NCT05921253

Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

Led by University of Oklahoma · Updated on 2026-01-26

104

Participants Needed

2

Research Sites

195 weeks

Total Duration

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AI-Summary

What this Trial Is About

This study is to determine if low level vagus nerve stimulation will lead to improvement in heart function, heart rate variation, and in the levels of certain chemical markers of inflammation in study participants' blood.

CONDITIONS

Official Title

Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy

Who Can Participate

Age: 18Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients over 18 years old who received anthracycline-based therapy for breast cancer or lymphoma within the last 30 days
  • Presence of at least one additional risk factor: previous chest radiation, age over 50, type 2 diabetes mellitus, hypertension, current smoking, obesity (BMI 6 30), previous myocardial infarction, established atherosclerotic heart disease, significant valve disease, or chronic kidney disease
Not Eligible

You will not qualify if you...

  • Atrial paced heart rhythm
  • History of seizure currently on treatment
  • History of vasovagal syncope
  • End stage liver or kidney disease

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 2 locations

1

Stephenson Cancer Center

Oklahoma City, Oklahoma, United States, 73104

Actively Recruiting

2

Stephenson Cancer Center- Tulsa

Tulsa, Oklahoma, United States, 74104

Not Yet Recruiting

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Research Team

S

SCC IIT Office

CONTACT

I

Ingrid Block

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

DEVICE_FEASIBILITY

Number of Arms

2

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