Actively Recruiting
Neuromodulation for Central Post-stroke Pain: Mechanism, Safety and Outcome
Led by Universitaire Ziekenhuizen KU Leuven · Updated on 2024-07-01
32
Participants Needed
1
Research Sites
166 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Central post-stroke pain (CPSP) is an often pharmacorefractory type of neuropathic pain that develops in 8% of stroke patients. CPSP has been treated with three distinct types of neuromodulation (deep brain stimulation of the sensory thalamus (Vc-DBS), motor cortex repetitive transcranial magnetic stimulation (M1-rTMS), and motor cortex stimulation (MCS)), but the level of evidence for these procedures is very low. Moreover, data on the changes in pain brain circuitry in CPSP, and the effect of neuromodulation on this circuitry is very limited.
CONDITIONS
Official Title
Neuromodulation for Central Post-stroke Pain: Mechanism, Safety and Outcome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to provide voluntary written informed consent prior to any screening procedures
- Male or female patients
- Aged 18 to 70 years
- Diagnosed with definite central post-stroke pain (CPSP) that is resistant to medications such as amitriptyline, lamotrigine, and pregabalin
You will not qualify if you...
- Aphasia
- Pregnancy or intention to become pregnant within the next year
- Medically unfit for surgery
- Unable to temporarily stop anticoagulation or anti-platelet medications
- Unable to undergo MRI, fMRI, or PET imaging
- Complete destruction of the stimulation target area (motor cortex or sensory thalamus)
- Uncontrolled seizures
- Expected to relocate within the next year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UZ Leuven
Leuven, Belgium, 3000
Actively Recruiting
Research Team
P
Philippe De Vloo, prof. dr.
CONTACT
D
Daan Remans
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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