Actively Recruiting
Neuromodulation and Cognitive Training in Opioid Use Disorder
Led by University of Minnesota · Updated on 2025-06-12
30
Participants Needed
1
Research Sites
354 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The relapsing nature of opioid use disorder is a major obstacle to successful treatment. About 90% of those entering treatment will relapse within one year. To improve treatment outcome, new interventions targeting the underlying brain biomarkers of relapse vulnerability hold significant promise in reducing this critical public health problem. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can modulate brain connectivity.
CONDITIONS
Official Title
Neuromodulation and Cognitive Training in Opioid Use Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years
- Abstinent from opioid use for 1 to 2 weeks
- Meet DSM-V criteria for opioid use disorder
- Ability to provide written consent and comply with study procedures
- Intend to remain in a 4-week supervised treatment program during the study
- May have current comorbid drug use but primary diagnosis must be opioid use disorder
- Recruited from the Lodging Plus Program at University of Minnesota Medical Center
You will not qualify if you...
- Medical conditions or treatments causing neurological damage (e.g., stroke, tumor, loss of consciousness over 30 minutes, HIV)
- Head injury causing skull fracture or loss of consciousness over 30 minutes
- Contraindications for tDCS or MRI (e.g., history of seizures, metal implants, pacemakers, pregnancy)
- DSM-V diagnosis of psychiatric disorders except lifetime depression
- Conditions preventing study measures from being administered or interpreted
- Age outside 18 to 60 years
- Primary substance use disorder diagnosis other than opioid (except caffeine or nicotine)
- Clinical evidence of Wernicke-Korsakoff syndrome
- Nicotine use will be recorded but not excluded
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55414
Actively Recruiting
Research Team
J
Jazmin Y Camchong, PhD
CONTACT
L
Lamisa N Chowdhury, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DEVICE_FEASIBILITY
Number of Arms
2
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