Actively Recruiting
Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans
Led by The University of Texas Health Science Center, Houston · Updated on 2026-05-05
250
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to explore the mechanisms of how transcranial magnetic stimulation (TMS) impacts fear circuits. The overarching objectives are to understand how varying TMS parameters affect targeted brain regions in order to optimize its impact on enhancing fear extinction memory consolidation in a population with known fear extinction deficiencies: post-traumatic stress disorder (PTSD). 250 subjects will take part in this research study across UTHealth Houston. The study will include preliminary screenings, baseline visits, and experimental visits across four days
CONDITIONS
Official Title
Neuromodulation of the Fear Extinction Circuit Using Temporally and Anatomically Specific TMS in Humans
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to provide informed consent
- For PTSD group: diagnosis of current PTSD
- For healthy control group: no current psychiatric disorders ("Axis I" disorders)
You will not qualify if you...
- History of seizures, significant head trauma, or other major neurological diseases
- Serious psychiatric diagnoses ("Axis I" disorders)
- Current significant suicidal thoughts or behavior in past 6 months
- Use of neuroleptics within one year prior to study
- Current substance use
- Pregnancy
- Metallic implants or devices that prevent MRI
- Taking medications that lower seizure threshold (with exceptions for stable bupropion use)
- Implanted devices or metal in the head (except dental implants)
- High risk of emotional or behavioral reactions or inability to understand consent
- For healthy controls: any current psychiatric diagnosis ("Axis I" disorders)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UTHealth Houston
Houston, Texas, United States, 77054
Actively Recruiting
Research Team
M
Mohammed Milad, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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