Actively Recruiting
Neuromodulation to Improve Grasping Function After SCI
Led by State University of New York at Buffalo · Updated on 2026-04-23
54
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2 randomized sessions to compare the effect of intermittent theta burst stimulation combined with paired corticospinal motoneuronal stimulation. In the second part of the study, 24 participants will complete either combined stimulation protocol or sham stimulation protocol with exercise training.
CONDITIONS
Official Title
Neuromodulation to Improve Grasping Function After SCI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages 18 to 75 years
- Chronic spinal cord injury of at least 1 year
- Cervical injury at C8 level or above
- Presence of motor evoked potential responses in at least one first dorsal interosseous muscle
You will not qualify if you...
- Uncontrolled medical problems including pulmonary or cardiovascular disease
- Major depression, psychosis, or altered cognitive status
- History of head injury or stroke
- Presence of metal plate in skull
- History of seizures
- Use of drugs that lower seizure threshold such as antipsychotic drugs
- Pregnant females
- Spinal cord diseases such as spinal stenosis, spina bifida, or herniated cervical disc
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The State University of New York at Buffalo
Buffalo, New York, United States, 14214
Actively Recruiting
Research Team
H
Hang Jin Jo, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
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