Actively Recruiting
Neuromodulation and Mindfulness Patients With AUD
Led by Charite University, Berlin, Germany · Updated on 2026-03-20
140
Participants Needed
1
Research Sites
171 weeks
Total Duration
On this page
Sponsors
C
Charite University, Berlin, Germany
Lead Sponsor
M
Medical School Berlin
Collaborating Sponsor
AI-Summary
What this Trial Is About
Our primary objective is to integrate tVNS and mindfulness meditation within a structured mindfulness-based relapse prevention (MBRP) program for detoxified alcohol-dependent patients (AD). We aim to determine whether neuromodulation can enhance mindfulness-based relapse prevention compared to mindfulness practice alone. In this context, we will investigate potential changes in the interaction of top-down control and cue reactivity, as well as assess the severity of AUD. Measurements of drinking behavior, cravings, and abstinence rates will be conducted up to three months post-treatment. Our second objective is to examine the causal role of frontal midline theta oscillations (FMΘ) in MBRP and cognitive control. To achieve this, we will first establish closed-loop amplitude-modulated transcranial alternating current stimulation (CLAM-tACS) to selectively modulate FMΘ oscillations during MBRP meditation exercises in AUD patients (2).
CONDITIONS
Official Title
Neuromodulation and Mindfulness Patients With AUD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Alcohol Dependence according to ICD-10
- Abstinent from alcohol for at least 3 days and no more than 12 months
You will not qualify if you...
- Current substance use disorder or dependence within the last 12 months other than alcohol
- Neurological disorders such as epilepsy, neuropathy, or multiple sclerosis
- Current severe major depressive disorder, manic episode, or schizophreniform disorder
- Use of anticonvulsive or high-potency antipsychotic medication
AI-Screening
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Trial Site Locations
Total: 1 location
1
Charité - Berlin University of Medicine
Berlin, State of Berlin, Germany, 10117
Actively Recruiting
Research Team
A
Annika Rosenthal
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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