Actively Recruiting
Neuromodulation and Neurorehabilitation for mTBI
Led by Northwestern University · Updated on 2026-05-08
200
Participants Needed
2
Research Sites
295 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation (iTBS), a type of repetitive transcranial magnetic stimulation and (ii) determine how APT + iTBS changes the neurocognitive system of attention in individuals with persistent attention deficits related to mTBI +/- PTSD.
CONDITIONS
Official Title
Neuromodulation and Neurorehabilitation for mTBI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- At least 18 years of age and no older than 80 years of age
- At least 3 months after experiencing a mild traumatic brain injury (mTBI) event
- History of mTBI with or without post-traumatic stress disorder (PTSD) confirmed by formal measures
- Report at least moderate severity on one or more cognitive complaints in the Neurobehavioral Symptom Inventory
You will not qualify if you...
- Currently participating in another research study
- Not fluent in English (speaking and reading)
- History of epilepsy before injury
- Receiving antiepileptic treatment for active seizures within the past 6 months
- Taking medications that lower seizure threshold, including antipsychotics, trazodone, and tramadol
- History of brain blood vessel surgery or heart valve surgery
- History of brain hemorrhage, neurovascular conditions, or neurodegenerative disorders
- Diagnosis or history of psychotic spectrum disorders (e.g., bipolar disorder, schizophrenia)
- Significant heart disease based on physician review
- Pregnant at enrollment or during study participation
- Contraindications for MRI or TMS/iTBS such as claustrophobia or metal in eyes, face, or brain
- Presence of cardiac pacemakers, defibrillators, cochlear implants, nerve stimulators, or intracranial metal clips
- Diagnosis of moderate or severe traumatic brain injury
- Mental health medication dosage changed within 30 days before screening
- Taking prescribed CNS stimulants and not willing to stop during study
- Positive test for opiates without prescription or high dose prescription opiates
- Poor test performance indicating questionable validity
- Active suicidal thoughts or recent attempts
- Increased intracranial pressure
- Moderate or severe cannabis use disorder
- Severe alcohol use disorder
- Baseline systolic blood pressure 170 or higher
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Northwestern University
Chicago, Illinois, United States, 60141
Actively Recruiting
2
Moody Neurorehabilitation Institute
Houston, Texas, United States, 77058
Actively Recruiting
Research Team
C
Catherine M Kestner
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
4
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