Actively Recruiting

Phase 4
Age: 18Years +
All Genders
NCT06112353

Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection

Led by University of California, Irvine · Updated on 2026-01-23

128

Participants Needed

1

Research Sites

119 weeks

Total Duration

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Sponsors

U

University of California, Irvine

Lead Sponsor

M

Merck Sharp & Dohme LLC

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this research study is to see the outcome of Sugammadex versus Neostigmine with Glycopyrrolate in colorectal surgery as it relates to its effects on post-surgical time (in hours) to first bowel movement and tolerance for solid food (GI-2 recovery) following bowel resection surgery

CONDITIONS

Official Title

Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 or older
  • Undergoing laparoscopic bowel resection surgery under general anesthesia
  • Use of nondepolarizing neuromuscular blockade with rocuronium or vecuronium
  • Requires inpatient admission
Not Eligible

You will not qualify if you...

  • Allergy to Rocuronium, Vecuronium, or Sugammadex
  • Bowel resection surgery requiring an ostomy
  • Severe valvulopathy, systolic heart failure with reduced ejection fraction, or coronary artery disease with positive stress test
  • Autoimmune pulmonary disease, severe pulmonary fibrosis, severe pulmonary hypertension
  • COPD requiring home oxygen
  • Pulmonary cancer (primary or metastatic)
  • Creatinine Clearance less than 30
  • Pregnancy
  • Unable to provide consent or understand the research project

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

UC Irvine Medical Center

Orange, California, United States, 92868

Actively Recruiting

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Research Team

D

David Whaley

CONTACT

R

Robert R Field, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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