Actively Recruiting
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
Led by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Updated on 2026-01-26
102
Participants Needed
1
Research Sites
18 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Osteoarthritis (OA) is a degenerative joint disease characterized by structural changes such as cartilage loss and osteophyte formation, leading to functional limitations and disability. Pain in knee OA involves a complex pathophysiological structure including both nociceptive and neuropathic mechanisms. Identifying the neuropathic pain component is clinically significant for improving quality of life and functional recovery. This cross-sectional controlled clinical study aims to determine the prevalence of neuropathic pain in patients with knee OA and evaluate its impact on pain severity and functional status. Patients will be categorized based on the Douleur Neuropathique 4 (DN4) questionnaire and assessed using various pain and functional scales.
CONDITIONS
Official Title
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with Knee OA according to ACR criteria
- Knee pain for more than 3 months
- Voluntary participation
You will not qualify if you...
- History of surgical intervention in the affected knee
- History of trauma to the affected knee within the last 6 months
- History of intra-articular injections or physical therapy involving the affected knee within the last 6 months
- Severe psychiatric disorders such as severe depression, anxiety disorder, or psychosis
- Diagnosis of central nervous system diseases including Parkinson's disease or multiple sclerosis
- Diagnosis of inflammatory arthritis such as Rheumatoid Arthritis or Ankylosing Spondylitis
- Severe cognitive impairment
- Chronic decompensated cardiac, renal, or hepatic failure
- Severe psychiatric, neurological, or cognitive disorders
- Decompensated cardiac, renal, or hepatic failure
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Istanbul Physical Medicine and Rehabilitation Training and Research Hospital
Istanbul, Turkey (Türkiye), 34186
Actively Recruiting
Research Team
E
Eser Kalaoglu, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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