Actively Recruiting
Neurophysiological and Behavioral Effects of Combining Transcranial Direct Current Stimulation (tDCS) and Modified-Constraint Induced Movement Therapy (mCIMT)
Led by King Saud University · Updated on 2025-01-22
300
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
K
King Saud University
Lead Sponsor
K
King Saud Medical City
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial aims to evaluate the effect of different types of tDCS modulation with mCIMT in improving affected upper-limb motor function for stroke patients. The main question it seeks to answer: Which type of tDCS (bi-hemispheric, anodal, or cathodal) combined with the mCIMT program leads to greater improvement in affected upper-limb function in patients with stroke? Researchers will compare these three types of tDCS to a sham tDCS. To see which kind of tDCS protocol combined with the mCIMT program will be more effective in improving affected upper-limb function for stroke patients. Participants will: 1. Participants will receive 12 sessions of mCIMT combined with tDCS or mCIMT alone. 2. Visit the clinic three times a week for four weeks. 3. Participants will do fMRI and TMS before and after the program and three times of assessment before and after two weeks after the program.
CONDITIONS
Official Title
Neurophysiological and Behavioral Effects of Combining Transcranial Direct Current Stimulation (tDCS) and Modified-Constraint Induced Movement Therapy (mCIMT)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults clinically diagnosed with ischemic or hemorrhagic stroke confirmed by imaging
- Age older than 18 years
- Stroke onset more than 3 months ago with unilateral motor deficits
- Adequate cognitive function with Arabic Mini Mental State Examination (MMSE) score of 24 or higher
- At least 10 degrees of active extension at the metacarpophalangeal and interphalangeal joints and 20 degrees at the wrist
- Fugl-Meyer Assessment scores between 19 and 58 indicating mild to moderate impairments
- Not participating in other clinical or research studies at the same time
You will not qualify if you...
- Severe muscle spasticity at all affected joints with Modified Ashworth Scale score greater than 3
- Contraindications to non-invasive brain stimulation
- Presence of unilateral neglect
- Other neurological or orthopedic conditions affecting hand function
- Unstable medical conditions
AI-Screening
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Trial Site Locations
Total: 1 location
1
King Saud University Medical City
Riyadh, Riyadh Region, Saudi Arabia, 12372
Actively Recruiting
Research Team
A
Alaa M. Albishi, PhD in Rehabilitation Sciences
CONTACT
A
Ahmad O. Alokaily, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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