Actively Recruiting
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
Led by University Hospital, Bordeaux · Updated on 2026-02-02
80
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries. Highly prevalent in older individuals from the general population, it represents a leading cause of stroke and a major contributor to cognitive decline and risk of dementia. Better detection and management of covert cSVD would have a major impact on preventing disability and costs related to stroke, cognitive impairment and dementia. The aim of the present study is to identify novel electroencephalographic (EEG) biomarkers of the cognitive deficits associated with cSVD, and how these biomarkers and cognitive performance are affected by personalized cognitive training or transcranial alternating current stimulation (tACS), a non-invasvie brain stimulation technique.
CONDITIONS
Official Title
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients included or previously included in the SHIVA cohort
- Basic computer skills (ability to open a browser, use a mouse and keyboard)
- Access to a personal computer with an internet connection
- Independent in Activities of Daily Living (ADL) with a score 65 5/6, and in Instrumental Activities of Daily Living (IADL) with a score 65 4/8
- Informed and written consent signed by the participant and the investigating physician for this study
You will not qualify if you...
- Motor impairments preventing the use of a keyboard and mouse (e.g., motor issues related to severe hand osteoarthritis)
- Depressive symptoms indicated by a score of 2 to 4 on the mini Geriatric Depression Scale (mini GDS), which includes 4 items
- Age-related macular degeneration (AMD)
- Untreated glaucoma
- Untreated psychiatric conditions that interfere with cognitive assessments
- Diagnosed attention deficit disorder with or without hyperactivity or patients who could not complete all cognitive tests required in the SHIVA cohort
- Systemic diseases that cause cognitive changes, such as obesity and metabolic disorders
- History of epilepsy or seizures
- Scalp sensitivity or skin lesions (dermatitis, wounds, etc.)
- Surgical clips, metal sutures, staples, stents
- Osteosynthesis material in the head or neck
- Pacemaker
- Implanted hearing aid
- Ocular foreign bodies, shrapnel, bullets
- Metalworker
- Pacemaker or neurostimulator
- Heart valve or endovascular material
- Ventricular shunt valve
- Recent exposure (< 6 months) to brain stimulation (tDCS, TMS, etc.)
- Ongoing participation in a clinical trial or cognitive training program
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU de Bordeaux, Hôpital Pellegrin, Unité Neurovasculaire
Bordeaux, France, 33000
Actively Recruiting
Research Team
I
IGOR SIBON, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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