Actively Recruiting
Neuroplasticity in Parkinson's Disease
Led by University of Minnesota · Updated on 2025-08-08
50
Participants Needed
1
Research Sites
401 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes to the emergence and expression of PD motor and non-motor signs. Neurophysiological biomarkers derived from this work may be important for the early detection and prediction of progression of disease. They can also provide the means to assess the efficacy of interventions designed to prevent or slow disease progression.
CONDITIONS
Official Title
Neuroplasticity in Parkinson's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with Parkinson's Disease diagnosed by a neurologist using PD Society Brain Bank criteria
- Not receiving levodopa or dopamine agonist treatment at the start of the study
- Able to walk independently without assistive devices for 50 meters
- Healthy controls matched by age (+/- 3 years) and sex to PD participants
- Healthy controls able to walk independently without assistive devices for 50 meters
You will not qualify if you...
- Diagnosed dementia or impaired capacity to consent
- History of musculoskeletal disorders affecting limb movement
- History of bipolar disorder, PTSD, or major depression
- Other neurological disorders affecting study participation
- Implanted deep brain stimulation or neurosurgery for Parkinson's
- Pregnancy
- History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury (for TMS experiments)
- Recent frequent fainting episodes due to blood, emotional, or sensory triggers (for TMS)
- Intracranial metallic or magnetic implants
- Pacemaker or implanted medical devices
- History of surgery on blood vessels, brain, or heart
- Unexplained recurring headaches or concussion in past six months
- Severe hearing impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Minnesota
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
Research Team
C
Colum MacKinnon, PhD
CONTACT
M
Madison Aasen
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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