Actively Recruiting
Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
Led by Xiangya Hospital of Central South University · Updated on 2025-11-18
1008
Participants Needed
1
Research Sites
92 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators designed LAPTOPS to determine the effectiveness of a goal-directed neuroprotection bundles of active management including body temperature,PaCO2,PaO2,position,Blood glucose ,blood sodium,Blood pressure and Lactate vs. usual care in adult post-cardiac arrest care. LAPTOPS is a large-scale pragmatic clinical trial to provide reliable evidence over the effectiveness of a widely applicable goal-directed care bundle in acute phase of adult post-cardiac arrest care.
CONDITIONS
Official Title
Neuroprotection Bundles For Comatose Survivors Following Cardiac Arrest
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older and under 80 years
- Patients with in-hospital or out-of-hospital cardiac arrest who have regained spontaneous circulation after CPR and required CPR for 20 minutes or less
- Patients unconscious after return of spontaneous circulation with FOUR motor response score under 4 or Glasgow Coma Scale 8 or less
- Family members or legal representatives provide signed informed consent
You will not qualify if you...
- Unwitnessed cardiac arrest with time from arrest to CPR start over 30 minutes
- Time from cardiac arrest to return of spontaneous circulation over 60 minutes
- Patients who woke up immediately after return of spontaneous circulation
- Presence of end-stage diseases
- Cardiac arrest caused by neurological diseases
- Patient was in a vegetative state before cardiac arrest
- Time from cardiac arrest to enrollment over 72 hours
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Xiangya hospital，Central South University
Changsha, Hunan, China, 410000
Actively Recruiting
Research Team
L
Lina Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
2
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