Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
NCT06473207

Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest

Led by Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer · Updated on 2026-04-13

48

Participants Needed

1

Research Sites

115 weeks

Total Duration

On this page

Sponsors

C

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Lead Sponsor

F

French Society for Intensive Care

Collaborating Sponsor

AI-Summary

What this Trial Is About

Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain injury. Despite current recommended advanced life support therapies, no specific treatment or procedure has yet been shown to improve the neurological outcome of such patients. Remote ischemic post-conditioning (RIPOST) which usually consists of applying brief and repeated cycles of ischemia alternating with reperfusion by inflating and deflating a blood pressure cuff or a pneumatic tourniquet placed around a limb, is a promising strategy to protect organs against I/R injury, including brain. Regarding cardiac arrest, pre-clinical studies have demonstrated an improvement in neurological outcome in animal subjects treated with RIPOST after cardiopulmonary resuscitation. The aim of our study is to demonstrate the benefit of early RIPOST in OHCA patients in reducing neurological injury and organ failure related to I/R syndrome.

CONDITIONS

Official Title

Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Out-of-hospital cardiac arrest with stable return of spontaneous circulation longer than 20 minutes
  • Patient receiving invasive mechanical ventilation for coma with Glasgow score less than 8
  • Availability of a lower limb without intravenous infusion or blood pressure cuff
  • Randomization and first session of intervention within 4 hours after return of spontaneous circulation
  • Consent obtained from next-of-kin or inclusion under emergency procedure
Not Eligible

You will not qualify if you...

  • Age under 18 years or pregnancy
  • Unable to walk without assistance or bedridden with severe disability (mRS of 4 or 5)
  • Interval between cardiac arrest and return of spontaneous circulation over 60 minutes
  • Unwitnessed cardiac arrest with asystole as first rhythm
  • Cardiac arrest occurring in hospital
  • Refractory cardiac arrest with no stable return of spontaneous circulation
  • Cardiac arrest from trauma, hemorrhage, stroke, or hanging
  • Persistent low mean arterial pressure below 65 mmHg despite treatment
  • Active uncontrolled bleeding
  • Contraindication to use of pneumatic tourniquet on both lower limbs
  • Use of extracorporeal arteriovenous circulation before inclusion
  • Previous inclusion in this study
  • Participation in another interventional study
  • Under judicial protection measures
  • Lack of French social security coverage

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer

Toulon, Var, France, 83100

Actively Recruiting

Loading map...

Research Team

C

Chelly Jonathan, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here