Actively Recruiting
Neuroprotective Effects of Long-term TaVNS in Early Parkinson's Disease Patients
Led by Kezhong Zhang · Updated on 2025-01-14
12
Participants Needed
1
Research Sites
75 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a randomized, double-blind, controlled trial exploring the effects of long-term taVNS intervention in patients with early-stage Parkinson's disease.
CONDITIONS
Official Title
Neuroprotective Effects of Long-term TaVNS in Early Parkinson's Disease Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55-75 years
- Diagnosed with idiopathic Parkinson's disease according to 2016 Chinese diagnostic criteria
- Hoehn and Yahr stage 2.5 or less at medication start
- Parkinson's disease duration of 3 years or less
- Receiving standard anti-Parkinson's disease medication treatment
You will not qualify if you...
- Cognitive impairment (MMSE < 24 or MoCA < 26), mental illness, or inability to cooperate
- Use of neuroprotective drugs or dopamine-affecting medications within 90 days before baseline
- Previous vagus nerve stimulation treatment
- MRI contraindications or significant brain abnormalities on MRI
- Contraindications for taVNS such as pacemakers, history of DBS surgery, or ear conditions
- Atypical or secondary Parkinsonian syndromes or drug/toxin-related symptoms
- Previous stroke or intracranial mass lesions
- Existing or potential cardiovascular diseases
- Eye diseases affecting eye movement
- Other neurological or musculoskeletal disorders affecting gait or balance
- Severe organic diseases with life expectancy under 2 years
- Participation in other clinical trials
- Inability to attend required treatment and follow-up due to location
- Upper limb tremor score of 3 or higher on UPDRS
- History of Parkinson's freezing episodes or falls
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China, 211200
Actively Recruiting
Research Team
K
Kezhong Zhang, Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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