Actively Recruiting
Neuropsychological Assessment of Children and Adolescents With Turner Syndrome
Led by University Hospital, Angers · Updated on 2024-12-30
70
Participants Needed
3
Research Sites
326 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Turner syndrome (TS) is a rare chromosomal disorder characterized by partial or complete loss of one of the X chromosomes that affects about one in every 2000 female babies born. These young patients described difficulties making friends, understanding others' emotions and intentions, and controlling their own emotions. Difficulties in these domains could led to social withdrawal, to reduced social skills and could have a significant impact on self esteem and mental health as well as on long-term academic and social functioning in affected individuals. The purpose of this project is to identify functional and dysfunctional cognitive and socio-cognitive abilities in these young patients which could account social difficulties described by some of them and their family. To this end, 35 girls with TS and 35 girls with isolated growth hormone deficiency and normal cerebral MRI will be recruited. Subjects will be 7 to 16 years and 11 months of age. Socio-cognitive and cognitive functions will be assessed with neuropsychological and experimental tasks. Questionnaires completed by patient, parents or teacher, will evaluate social and behavioral functioning.
CONDITIONS
Official Title
Neuropsychological Assessment of Children and Adolescents With Turner Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Girls diagnosed with Turner syndrome for the Turner syndrome group
- Girls diagnosed with isolated growth hormone deficiency for the isolated GHD group
- Age between 7 years and 16 years 11 months
- Informed consent signed by the participant and her parents or legal representatives
- Registered in the national social security system
You will not qualify if you...
- Presence of chronic diseases other than Turner syndrome in the Turner syndrome group
- Presence of part of a Y chromosome or r(X) cases in karyotype for Turner syndrome group
- Receiving medical treatments other than those usually prescribed for Turner syndrome patients
- Presence of chronic diseases other than isolated growth hormone deficiency in the isolated GHD group
- Receiving medical treatments other than those usually prescribed for isolated growth hormone deficiency patients
- Diagnosed intellectual disability (IQ less than 70) or intellectual giftedness
- History of acquired brain injury
- Auditory or visual sensory disturbances that prevent completion of neuropsychological tasks
- Insufficient proficiency in the French language
AI-Screening
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Trial Site Locations
Total: 3 locations
1
CHU Rennes
Rennes, Ile Et Vilaine, France, 35056
Actively Recruiting
2
CHU Nantes
Nantes, Loire Atlantique, France, 44300
Actively Recruiting
3
CHU Angers
Angers, Maine Et Loire, France, 49933
Actively Recruiting
Research Team
R
Régis Coutant, MD PhD
CONTACT
E
Emmanuel Quemener, CRA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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