Assessment of Thinking and Social Skills in Girls Aged 7 to 16 Years With Turner Syndrome or Growth Hormone Deficiency

What this Trial Is About

Turner syndrome is a rare chromosomal disorder affecting about one in every 2000 female babies, characterized by partial or complete loss of one X chromosome. Girls with Turner syndrome often face challenges in making friends, understanding emotions, and controlling their own emotions, which can impact their social skills, self-esteem, mental health, and long-term academic and social functioning. This research aims to identify the cognitive and social-cognitive abilities that may explain these difficulties by comparing girls with Turner syndrome to girls with isolated growth hormone deficiency aged 7 to 16 years and 11 months. The study is observational and involves two groups 35 girls with Turner syndrome and 35 girls with isolated growth hormone deficiency, all within the same age range. Neuropsychological and experimental tasks will assess cognitive, social, and affective functions. Questionnaires completed by the participants, their parents, or teachers will evaluate social and behavioral functioning. The study involves two half-day visits the first visit takes place at the participants regular monitoring center immediately after the inclusion visit, and the second visit occurs in the participants home within three months. Participants will undergo comprehensive assessments conducted by neuropsychologists, including tests of intelligence, theory of mind, emotional recognition, executive abilities, self-esteem, depression, anxiety, and social adjustment. These evaluations will help measure cognitive and socio-affective functions. The total participation time includes two half-day visits spaced up to three months apart. The studys primary outcomes focus on detailed neuropsychological measures to better understand the social difficulties experienced by girls with Turner syndrome.

Neuropsychological Assessment of Children and Adolescents With Turner Syndrome