Actively Recruiting
A Neurosensory Account of Anxiety and Stress (Study 2)
Led by The University of Texas Health Science Center, Houston · Updated on 2025-09-12
160
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center, Houston
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will take a basic neuroscience approach to investigate pathological mechanisms underlying PTSD. Additionally, the study aims to identify how Transcranial Alternating Current Stimulation (tACS) brain stimulation can modulate and correct neural networks and related emotions of anxious arousal and hypervigilance, with the goal of assessing tACS brain stimulation technology as a novel intervention for symptoms of anxiety.
CONDITIONS
Official Title
A Neurosensory Account of Anxiety and Stress (Study 2)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Right-handed
- Normal or corrected-to-normal vision and normal olfaction
- Between 18 and 50 years old
- Meet tACS screening criteria (e.g., no serious head injury or loss of consciousness)
- Diagnosis of PTSD (for patients)
- Stable psychotropic medication use for past 2 months (for patients on medication)
- Abstained from substance use 48 hours before experiment (for mild substance use or occasional use)
You will not qualify if you...
- History of major medical illnesses (e.g., cancer, metabolic syndrome, cardiovascular, inflammatory disorders) or neurological disorders (e.g., seizure, stroke, Parkinson's disease)
- Concurrent Axis I diagnosis in patients (except depression, anxiety, mild substance use disorder)
- Healthy controls with any DSM-5 Axis I disorder diagnosis or current psychoactive medication use
- Severe psychiatric instability or acute life crises including active suicidality or homicidality
- History of head trauma with unconsciousness longer than 5 minutes
- Regularly drinking 3 or more alcoholic beverages daily
- Unable to abstain from substances or sleep medication 48 hours before scanning
- Use of calcium channel blockers or alpha-blockers without ability to stop 48 hours before scanning
- Failed urine drug screening test
- Pregnancy
- Presence of electrically, magnetically, or mechanically activated implants (e.g., pacemakers)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
W
Wen Li, PhD
CONTACT
J
Jada Malveaux, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here