Actively Recruiting
Neurovascular Transduction During Exercise in Chronic Kidney Disease
Led by Emory University · Updated on 2025-03-05
150
Participants Needed
3
Research Sites
482 weeks
Total Duration
On this page
Sponsors
E
Emory University
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and to explore what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate). This study will also test whether or not regular exercise on a bicycle and/or treatment with 6R-BH4 (Kuvan) pills, or histidine and beta-alanine supplementation improves these measures during exercise. 6R-BH4 is currently FDA-approved for use in patients with certain forms of a disease called phenylketonuria, but it is not currently FDA approved for blood pressure or exercise capacity in people with CKD.
CONDITIONS
Official Title
Neurovascular Transduction During Exercise in Chronic Kidney Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Stage III or IV chronic kidney disease with estimated glomerular filtration rate (eGFR) between 15 and 59 cc/minute
- Stable kidney function with less than 30% decrease in eGFR over past 3 months
- Exercising less than 20 minutes twice per week
- Willing and able to follow the study protocol
- Control participants also must exercise less than 20 minutes twice per week and be willing and able to cooperate with the study
You will not qualify if you...
- Severe chronic kidney disease with eGFR less than 15 cc/minute
- Ongoing drug or alcohol abuse
- Diabetic neuropathy
- Serious systemic diseases affecting survival
- Severe anemia with hemoglobin below 9 g/dL
- Congestive heart failure or ejection fraction below 35%
- Symptomatic heart disease by tests or history
- Treatment with central alpha agonists like clonidine
- Uncontrolled high blood pressure above 170/100 mm Hg
- Low blood pressure below 100/50 mm Hg
- Pregnancy or planning pregnancy
- Current treatment with monoamine oxidase (MAO) inhibitors
- Inability to exercise on a stationary bicycle
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
2
Emory University Hospital
Atlanta, Georgia, United States, 30322
Actively Recruiting
3
Atlanta VA Health Care System
Decatur, Georgia, United States, 30033
Actively Recruiting
Research Team
J
Jeanie Park, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
6
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here