Actively Recruiting
Neutrophil Extracellular Traps Formation in Breast Cancer Patients Taking Tamoxifen
Led by M.D. Anderson Cancer Center · Updated on 2026-05-01
290
Participants Needed
1
Research Sites
265 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study examines the long-term effects of tamoxifen (TAM) treatment on excessive production of neutrophil extracellular traps (NET) and their impact on breast cancer and side effects. NET are produced by the body to fight infections but have also been linked to side effects caused by the body's immune system. Treatment with tamoxifen increases the production of NETs. This study may help researchers determine if the increased number of NETs in the body has a damaging effect in breast cancer.
CONDITIONS
Official Title
Neutrophil Extracellular Traps Formation in Breast Cancer Patients Taking Tamoxifen
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Age 18 to 45 years, or 46 to 50 years if menstrual cessation has not occurred for 12 consecutive months
- Age 51 years or older with menopause defined as cessation of menstrual cycle for 12 consecutive months
- Diagnosed with estrogen receptor-positive breast cancer
- Being treated with tamoxifen for at least 6 months
- Control subjects: Newly diagnosed estrogen receptor-positive breast cancer patients on tamoxifen for 0 to 6 months in the same age groups
You will not qualify if you...
- Pregnant women
- History of severe congenital neutropenia due to specific genetic disorders such as Kostmann Disorder, ELA2 gene mutation, Wiskott-Aldrich syndrome, GFI1 gene mutation, CSF3R gene mutation, Schwachman-Diamond Syndrome, Barth Syndrome, WHIM Syndrome, or Chadiak-Higashi Syndrome
- History of autoimmune disorders including rheumatoid arthritis, lupus, Crohn's disease, multiple sclerosis, and psoriasis
- History of chronic viral infections such as HIV or hepatitis
- Recent positive test for coronavirus disease (COVID)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Jyotika Sharma
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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