Study of Neutrophil Behavior and Acute Lung Injury in Infants Undergoing Cardiopulmonary Bypass Surgery

What this Trial Is About

Researchers are investigating acute lung injury ALI that can occur after cardiopulmonary bypass CPB surgery, a serious complication that affects pediatric patients undergoing cardiac surgery. This study aims to understand how CPB causes ALI by looking at the role and behavior of neutrophils, a type of immune cell, in lung injury following CPB. ALI can lead to increased lung damage and even acute respiratory distress syndrome, which has a high mortality rate in affected patients. The study involves collecting blood and tracheal aspirate samples from pediatric patients scheduled for cardiac surgery with CPB. Patients are grouped based on the length of CPB they undergo, either longer or shorter durations. The research focuses on analyzing neutrophil behavior, including their movement and activation, as well as measuring chemokine levels and neutrophil functions that could contribute to lung injury after CPB. During the study, researchers will perform detailed neutrophil analysis from collected samples over a period of two years. They will assess neutrophil migration, activation, and the release of substances that may damage lung tissue. The study will monitor these immune responses to better understand the mechanisms behind ALI in pediatric patients following CPB surgery. Participant involvement includes sample collection and clinical monitoring, with outcomes focused on immune cell profiling and lung injury markers.

Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)