Actively Recruiting
A New Breath for Malignant Hypertension Implementation of the HAMA Cohort
Led by Centre Hospitalier de PAU · Updated on 2026-03-23
1200
Participants Needed
37
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Malignant hypertension is a very serious form of high blood pressure that can be fatal if untreated. This research aims to create the first large, multicenter database to better understand this disease, including its modern epidemiology, how patients are currently managed, and the diseases diagnostic criteria. The study will help improve knowledge and may lead to new treatment trials and evidence-based recommendations. The study is an observational registry enrolling patients diagnosed with malignant hypertension based on classic definitions, including severe blood pressure elevation and organ damage. It plans to recruit 500 patients and follow them for five years to study their prognosis and the impact of different patient characteristics and organ involvement. By collecting detailed data on disease features and care pathways, the study hopes to update definitions and management approaches. Participants will be observed over five years, with researchers collecting information on their health status, organ damage, and treatment. The main outcome measured is the five-year prognosis of patients. This long-term follow-up will provide detailed knowledge about the disease course and help identify factors influencing outcomes, without any study treatments or interventions being assigned.
CONDITIONS
Brief Title
A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Malignant hypertension according to the classic definition (severe hypertension above 180/110 with severe hypertensive retinopathy)
- Severe hypertension above 180/110 with acute damage to three target organs due to high blood pressure
- Adults aged 18 years or older
You will not qualify if you...
- Younger than 18 years old
- Patients unable to freely give consent or who refuse to participate
- Patients currently on dialysis
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