Actively Recruiting
New Clinical Decision Support Score Based on Steroid Hormone Profiling in the Diagnosis of MACS
Led by University Hospital, Bordeaux · Updated on 2026-01-20
291
Participants Needed
1
Research Sites
75 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The recent development of quantitative steroid metabolome profiling could be of interest for the positive diagnosis of mild autonomous cortisol-secreting adenoma (MACS). The aim of the study is to develop a predictive model of MACS status or non-secreting adenoma (NSA) based on a panel of 19 serum steroids and three clinico-biological parameters (body mass index or BMI, fasting glycaemia, blood pressure) and to estimate its performance for the diagnosis of MACS in a cohort of patients followed in the endocrinology department of Bordeaux University Hospital.
CONDITIONS
Official Title
New Clinical Decision Support Score Based on Steroid Hormone Profiling in the Diagnosis of MACS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years or older
- One or more unilateral or bilateral adrenal nodules with spontaneous density less than 20 HU on CT and size at least 1 cm without overt hormonal secretion
- Alternatively, adrenal nodules not meeting density criteria but stable in size after at least 6 months follow-up and without overt hormonal secretion
- Written informed consent before any research examinations
- Affiliated with or benefiting from social security
- For MACS group: at least two elevated 1mg dexamethasone suppression tests (cortisol >50 nmol/L or 1.8 µg/dL) and plasma ACTH ≤ 20 pg/mL
- For ANS group: normal 1mg dexamethasone suppression test (cortisol ≤ 50 nmol/L or 1.8 µg/dL)
- Controls: patients without known adrenal pathology with normal 1mg dexamethasone suppression test, matched for age and sex
You will not qualify if you...
- Adrenal incidentaloma smaller than 1 cm
- Use of systemic or local corticosteroids (inhaled, eye/ear drops, ointments, skin products, joint infiltration) in past 6 months
- Use of drugs interfering with dexamethasone metabolism
- Pregnancy
- Any life-threatening condition
- Active illness at blood sampling (fever, COVID-19 infection, influenza)
- Urinary free cortisol above normal laboratory limit
- Patients under court protection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hôpital du Haut-Lévêque
Pessac, France, 33604
Actively Recruiting
Research Team
A
Amandine FERRIERE
CONTACT
J
Julie Brossaud
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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