Actively Recruiting
New Methods for Evaluating Preventive Migraine Treatment
Led by University of Aarhus · Updated on 2026-04-13
60
Participants Needed
2
Research Sites
182 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study aims to test interactions between drug and placebo-responses in acute migraine treatment and to assess variation in adverse events according to treatment information provided. Using a clinical within-subjects, balanced placebo design, patients with chronic migraine will receive four treatment conditions in a randomized order.
CONDITIONS
Official Title
New Methods for Evaluating Preventive Migraine Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 65 years
- History of migraine with or without aura for at least 1 year based on International Classification of Headache Disorders criteria
- Diagnosed with chronic migraine before age 65, defined as headaches on 15 or more days per month for over 3 months, with migraine features on at least 8 days per month
- Eligible for preventive migraine treatment
- Ability to speak and read Danish
You will not qualify if you...
- Use of onabotulinumtoxinA as preventive migraine treatment in the 4 months before joining the study
- Use of other preventive migraine treatments except CGRP antagonists, except stable doses of antidepressants, calcium channel blockers, beta blockers, or antiepileptics for at least 2 months before joining and during the study
- Use of migraine prevention devices like transcranial magnetic stimulation or nerve blocks within 3 months before joining
- Use of opioid or barbiturate medications within 4 weeks before joining
- Having secondary headache disorders including medication overuse headache
- Severe psychiatric disorders, vascular disease, or known liver disease
- Alcohol or substance abuse
- Current or planned pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Department of Psychology and Behavioral sciences, Aarhus BSS, Aarhus University
Aarhus C, Denmark, Denmark, 8000
Actively Recruiting
2
Department of Neurology, Aarhus University Hospital
Aarhus N, Denmark, Denmark, 8200
Actively Recruiting
Research Team
S
Sigrid Juhl Lunde, MSc, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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