Actively Recruiting
New Preclinical and Clinical Approaches to Mesothelioma
Led by Marco Emilio Bianchi · Updated on 2024-08-02
70
Participants Needed
2
Research Sites
130 weeks
Total Duration
On this page
Sponsors
M
Marco Emilio Bianchi
Lead Sponsor
I
Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study protocol involves the coordination between UO1 (IRCCS San Raffaele Hospital) and UO2 (Istituto Nazionale Tumori di Napoli - IRCCS G. Pascale) to explore the role of HMGB1 and CXCR4 in cancer treatment and metastasis. UO1 focuses on the role of HMGB1 in inflammation, mesothelioma progression, and tissue repair, as well as developing, in future, possible HMGB1 inhibitors for cancer therapy. UO2 specializes in CXCR4's role in cancer, developing CXCR4 antagonists, and tracking CXCR4-dependent metastasis. The hypothesis is that targeting HMGB1 and CXCR4 pathways will inhibit tumor progression and metastasis, enhancing anti-tumor immunity and improving therapeutic outcomes in cancer.
CONDITIONS
Official Title
New Preclinical and Clinical Approaches to Mesothelioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with clinical suspicion or histologically confirmed pleural mesothelioma
- Candidates for surgical intervention
- Age 18 years or older
- Both male and female patients, including reproductive age and breastfeeding women
- Ability to understand the study and provide autonomous informed consent
- Control group patients with other histologically confirmed diseases (neoplastic, inflammatory, or infectious) without pleural mesothelioma
- Control group candidates for surgical intervention
- Control group patients aged 18 years or older
- Control group includes both male and female patients, including reproductive age and breastfeeding women
- Control group ability to understand the study and provide autonomous informed consent
You will not qualify if you...
- Lack of biopsy material
- Pregnancy
- Unwillingness to sign the Informed Consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Istituto Nazionale Tumori IRCCS Fondazione G.Pascale
Naples, Campania, Italy, 80131
Actively Recruiting
2
IRCCS San Raffaele
Milan, Lombardy, Italy, 20132
Actively Recruiting
Research Team
M
Massimo Crippa, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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