Study of Environmental and Microbiome Effects on Moderate to Severe Atopic Asthma in Adults Aged 18 to 60

What this Trial Is About

Researchers are conducting a long-term observational study to better understand how environmental factors and bacteria impact moderate to severe atopic asthma in adults aged 18 to 60. The study aims to explore the natural history of asthma by collecting samples and data over time, focusing on how environmental exposures relate to asthma symptoms, disease progression, and response to therapy. About 200 participants will be enrolled in this exploratory single-center study. Participants will provide various samples including blood, urine, DNA, saliva, sputum, stool, and household dust. Some may also participate in an optional bronchoscopy visit involving airway examination and cell sample collection. The study includes regular visits every six months for five years, with additional sick visits available as needed. During visits, participants will undergo medical history reviews, physical exams, lung function tests, and surveys about asthma symptoms and quality of life. Throughout the study, participants will have asthma check-ups and receive standard asthma care at no cost. Samples and questionnaires collected will help researchers study microbiological and genetic influences on asthma. Some participants will use home devices for additional data collection. The study will monitor participants for up to five years, supporting future asthma research and possible study expansion.

NHALES (Natural History of Asthma With Longitudinal Environmental Sampling)