Actively Recruiting
Nicotinamide Riboside Clinical Trial for GWI
Led by Roskamp Institute Inc. · Updated on 2025-07-24
52
Participants Needed
2
Research Sites
194 weeks
Total Duration
On this page
Sponsors
R
Roskamp Institute Inc.
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
In this multi-site trial, we will use a randomized, double-blind, placebo-controlled study design to test whether 300 mg of Nicotinamide Riboside (NR) can achieve the primary objective of increasing plasma NAD+ levels in participants with Gulf War Illness (GWI).
CONDITIONS
Official Title
Nicotinamide Riboside Clinical Trial for GWI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 47 to 70 years, any gender and ethnic group
- Willing and able to give informed consent
- Medically stable as determined by the investigator
- Negative pregnancy test for females of childbearing potential
- Females of childbearing potential must use effective birth control during the study and for 30 days after last dose
- Veterans deployed to the Gulf War between August 1990 and August 1991
- Meet criteria for CDC Chronic Multisymptom Illness or Kansas Gulf War Illness definitions
- Weight between 50.0 kg and 200.0 kg (110 lbs to 440 lbs)
You will not qualify if you...
- Diagnosed medical or psychiatric conditions that could explain symptoms or interfere with reporting
- Females who are pregnant, nursing, or unwilling/unable to use birth control if of childbearing potential
- Allergy or sensitivity to nicotinamide riboside, vitamin B3, or capsule ingredients
- Significant medical conditions affecting study conduct (e.g., untreated hypertension, recent heart attack, renal or hepatic failure, chemotherapy)
- Abnormal clinical lab values as judged by investigator
- Poor venous access
- Use of NR or related supplements within 30 days of screening
- Participation in other clinical trials with dietary or drug intervention within 90 days before screening
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Nova Southeastern University
Fort Lauderdale, Florida, United States, 33314
Actively Recruiting
2
The Roskamp Institute
Sarasota, Florida, United States, 34243
Actively Recruiting
Research Team
D
Dakota Helgager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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