Actively Recruiting
Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)
Led by The University of Texas Health Science Center, Houston · Updated on 2025-09-12
15
Participants Needed
1
Research Sites
176 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine whether SMDS patients treated with NR at the proposed dose exhibit decreased glucose uptake in the aorta, to determine if NR treatment results in measurable changes of blood NAD+ and NR levels, to determine if aortic measurements are stable after treatment with NR and to evaluate the safety and tolerability of NR in SMDS patients.
CONDITIONS
Official Title
Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals diagnosed with SMDS with confirmed ACTA2 mutation disrupting arginine 179
- Parental or guardian permission (informed consent) and, if appropriate, child assent
You will not qualify if you...
- History of surgery to replace aneurysmal or dissected ascending and root aortic tissue with a graft
- Additional medical conditions impairing ability to participate in the study
- Known allergy or sensitivity to niacin or nicotinamide riboside
- Prior use of niacin or nicotinamide riboside supplements within the last eight weeks
- Failure to provide informed consent
- Concurrent participation in another intervention trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
D
Dianna M Milewicz, MD, PhD
CONTACT
D
David R Murdock, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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