Actively Recruiting
Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis
Led by Haukeland University Hospital · Updated on 2024-01-11
300
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the safety and efficacy of Nicotinamide riboside (NR) for treatment of patients with progressive multiple sclerosis. The main question it aims to answer is: • Does NR delay disability progression in progressive multiple sclerosis? Participants will be treated with NR or placebo for 30 months,
CONDITIONS
Official Title
Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with progressive multiple sclerosis (secondary SPMS or primary PPMS) using 2013 and 2017 clinical criteria
- Aged between 18 and 65 years
- Expanded Disability Status Scale (EDSS) score between 3 and 6.5
- Able to perform the Timed 25-Foot Walk (T25FW) test
- Documented disability progression during the 24 months before screening
- With or without stable disease-modifying therapy for at least 3 months
- Provided written informed consent to participate
You will not qualify if you...
- Diagnosed with relapsing multiple sclerosis
- Having any neoplastic disease at baseline
- Prior history of malignant melanoma or breast cancer
- Being in a stable phase of progressive disease course
- Pregnant or breastfeeding females
- Diagnosed with dementia or other neurodegenerative disorders at baseline
- Psychiatric or physical comorbidities that prevent study participation
- Used high-dose vitamin B3 supplements within 30 days before enrollment
- Confirmed genetic mitochondrial or metabolic disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Haukeland University Hospital
Bergen, Norway, 5019
Actively Recruiting
Research Team
K
Kjell-Morten Myhr
CONTACT
Ø
Øivind Torkildsen
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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