Actively Recruiting
Nicotinamide Riboside in Ulcerative Colitis
Led by University of Pittsburgh · Updated on 2026-01-20
40
Participants Needed
1
Research Sites
121 weeks
Total Duration
On this page
Sponsors
U
University of Pittsburgh
Lead Sponsor
C
Crohn's and Colitis Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a randomized, double-blind pilot study of Nicotinamide Riboside (NR) in Pediatric-onset Ulcerative Colitis (UC).
CONDITIONS
Official Title
Nicotinamide Riboside in Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pediatric patients 18 years old or younger
- Diagnosis of mild to moderate ulcerative colitis confirmed by Pediatric Ulcerative Colitis Activity Index and endoscopic Mayo scoring at colonoscopy
- Newly diagnosed (treatment naive) or patients with established disease
You will not qualify if you...
- Patients with acute severe ulcerative colitis
- Concurrent gastrointestinal infections such as Clostridium difficile or Cytomegalovirus
- Diagnosis of Crohn's disease
- Indeterminate colitis or inflammatory bowel disease unclassified
- Treatment with steroids or antibiotics in the past three months (patients on biologic medications with stable dose for at least three months may be enrolled)
- Other chronic inflammatory or autoimmune disorders or prior malignancy
- Pregnant women; women of childbearing age must use contraception at inclusion
- Existing kidney or liver dysfunction
- Platelet count less than 50,000 preventing endoscopy per standard care guidelines
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
Research Team
M
Min Shi
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
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