Actively Recruiting
Night-shift Work and Breast Cancer
Led by IRCCS Azienda Ospedaliero-Universitaria di Bologna · Updated on 2025-01-22
6000
Participants Needed
2
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Scientific evidence established about the effects of night work on health both in the short term (insomnia, excessive sleepiness, difficulty concentrating or lack of energy) and in the long term (moderately high risk of developing cardiovascular disease, type 2 diabetes, depression, cancer). In light of the scientific evidence, the IARC (International Agency for Research on Cancer) has listed night work as a probable human carcinogen (Group 2). With respect to current knowledge, the present study could provide valuable help in understanding the mechanisms by which circadian rhythm alteration acts at the genetic level in terms of promoting oncogenesis. Furthermore, by studying its association with other risk factors, understand whether there is a pattern of women more susceptible to its oncopromoting action.
CONDITIONS
Official Title
Night-shift Work and Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female health workers with any contract and qualification at IRCSS AOUBO and AOU "G. Martino" of Messina
- At least six months of service between January 1, 2000, and December 31, 2021
- Age between 20 and 70 years at the start of study follow-up
- For secondary objectives, women exposed to night work must have worked at least 6 night shifts per month in the past six months
You will not qualify if you...
- Women positive for BRCA1 or BRCA2 genetic mutations
- Women with a prior history of breast cancer at recruitment or within six months after
AI-Screening
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Trial Site Locations
Total: 2 locations
1
IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Medicina del Lavoro
Bologna, Italy, 40138
Actively Recruiting
2
AOU G. Martino Messina U.O.S.D. Medicina del Lavoro
Messina, Italy, 98125
Actively Recruiting
Research Team
F
Francesco Violante Violante, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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