Actively Recruiting

Phase Not Applicable
Age: 12Years - 18Years
All Genders
NCT05662280

NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits

Led by Bradley Hospital · Updated on 2026-05-01

40

Participants Needed

1

Research Sites

208 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23

CONDITIONS

Official Title

NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits

Who Can Participate

Age: 12Years - 18Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Ability to provide assent and parental permission
  • Participant and parent/legal guardian are fluent in English
  • Age between 12 and 18 years
  • Parent rating on BRIEF-2 Working Memory greater than 1.0 standard deviation above the normative mean
  • IQ greater than 80
  • Clinical diagnosis of ADHD of any type confirmed by NICHQ Vanderbilt Assessment Scales-Parent
Not Eligible

You will not qualify if you...

  • Intracranial pathology from known genetic or acquired neurological disorders or history of severe head injury
  • History of fainting spells of unknown cause that might be seizures
  • Personal or immediate family history of seizures or epilepsy
  • Any progressive neurological disorder
  • Uncontrolled chronic medical conditions that could cause emergencies in case of seizures
  • Contraindicated metal implants in the head, brain, or spinal cord (except dental implants, braces, or fillings)
  • Non-removable makeup or piercings
  • Presence of pacemaker, implanted medication pump, vagal nerve stimulator, deep brain stimulator, or TENS unit (unless removed)
  • Ventriculo-peritoneal shunt
  • Signs of increased intracranial pressure or intracranial lesions
  • History of head injury with prolonged loss of consciousness
  • Substance abuse or dependence within past six months
  • Chronic use of prescription medications lowering seizure threshold (except safe psychostimulants)
  • Active psychosis or mania
  • Current suicidal intent
  • Current pregnancy
  • Significant visual, hearing, or speech impairment
  • Current wards of the state

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

E. P. Bradley Hospital

East Providence, Rhode Island, United States, 02915

Actively Recruiting

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Research Team

B

Brian Kavanaugh, PsyD ABPP

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

BASIC_SCIENCE

Number of Arms

2

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