Actively Recruiting
NIS on the Benefits of TIPS in Patients With HCC Receiving Atezo+Bev in 1st-Line Therapy
Led by Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest · Updated on 2026-02-05
350
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
Sponsors
I
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest
Lead Sponsor
R
Roche Pharma AG
Collaborating Sponsor
AI-Summary
What this Trial Is About
The NISTIPS TRITICC-4 study is a prospective, multicentre, non-interventional cohort study to analyze the effectiveness of transjugular intrahepatic portosystemic shunting (TIPS) in patients with Hepatocellular carcinoma (HCC) receiving atezolizumab plus bevacizumab as first-line treatment. It will further characterize the effectiveness of atezolizumab and bevacizumab therapy, investigate post-market safety and evaluate health-related quality in HCC patient cohorts with or without TIPS in a real-world setting.
CONDITIONS
Official Title
NIS on the Benefits of TIPS in Patients With HCC Receiving Atezo+Bev in 1st-Line Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older
- Histologically confirmed locally advanced, metastatic, or unresectable hepatocellular carcinoma
- Presence of liver cirrhosis confirmed by histology, liver stiffness, ultrasound, endoscopy, or blood tests
- Disease not suitable for curative surgery or locoregional therapies, or progressive disease after such treatments
- Decision made by treating physician to use atezolizumab plus bevacizumab with or without TIPS
- Patients who have received 1-2 cycles of atezolizumab plus bevacizumab before enrollment are eligible if treatment decisions are separate from study inclusion
You will not qualify if you...
- Lack of signed informed consent
- Under 18 years old at time of consent
- Inability to understand the implications of study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital of Düsseldorf
Düsseldorf, North Rhine-Westphalia, Germany, 40225
Actively Recruiting
Research Team
C
Christoph Roderburg, Professor
CONTACT
B
Bianca Zaepf
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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