Actively Recruiting
Nitrous Oxide Neuroimaging
Led by Keith M Vogt · Updated on 2026-04-15
60
Participants Needed
1
Research Sites
72 weeks
Total Duration
On this page
Sponsors
K
Keith M Vogt
Lead Sponsor
N
National Institute of General Medical Sciences (NIGMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
CONDITIONS
Official Title
Nitrous Oxide Neuroimaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have none of the specific exclusion criteria
- Have a valid email address and phone number throughout the study
- Free from any non-MRI compatible implants
You will not qualify if you...
- Are pregnant or trying to conceive
- Body mass index (BMI) greater than 35
- Significant memory impairment or hearing loss
- Sleep apnea
- Chronic pain or frequent use of pain medication, including tramadol
- Any severe or poorly-controlled medical problem such as hypertension or diabetes
- Neurologic or psychiatric diseases, including anxiety and depression
- Severe cardiac disease
- History of methylenetetrahydrofolate reductase (MTHFR) deficiency or variant mutation
- Recent ear or eye surgery
- Claustrophobia
- Have metal implants or non-removable metal piercings
- History of adverse reactions to anesthetics
- Daily alcohol or heavy alcohol use; history of alcohol abuse
- Current daily smoker
- Regular or recent marijuana use, including prescribed medical marijuana
- Illicit drug use (street drugs)
- Regular use of antiepileptics, antidepressants, antipsychotics, antihistamines, anti-anxiety medications, stimulants, or sleep aids
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
K
Keith M Vogt, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here